Related Experiment Video
Updated: Nov 1, 2025
An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient
Published on: November 30, 2022
Characteristics and outcomes of patients hospitalized for COVID-19 in France: The Critical COVID-19 France (CCF)
Guillaume Bonnet1, Orianne Weizman2, Antonin Trimaille3
1Université de Paris, PARCC, inserm, 75015 Paris, France; Hôpital Européen Georges-Pompidou, Université de Paris, 75015 Paris, France.
Insights
This study found that cardiovascular risk factors like diabetes and hypertension significantly increased the risk of death in hospitalized COVID-19 patients in France. Older age and male sex also contributed to higher mortality rates.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- The COVID-19 pandemic caused a global health crisis.
- Limited data existed on hospitalized COVID-19 patients in France.
Purpose of the Study:
- To analyze characteristics of COVID-19 patients hospitalized in France.
- To investigate cardiovascular complications and outcomes in these patients.
Main Methods:
- The Critical COVID-19 France (CCF) study included adult patients hospitalized with SARS-CoV-2 infection.
- Data collected included clinical, biological, and imaging parameters.
- The primary endpoint was in-hospital mortality.
Main Results:
- Of 2878 patients, 12.5% died in-hospital.
- Most patients had cardiovascular risk factors, including hypertension (50.8%) and diabetes (23.7%).
- Older age, male sex, diabetes, chronic kidney failure, elevated troponin, elevated BNP/NT-proBNP, and high qSOFA scores were linked to increased in-hospital death.
Conclusions:
- Cardiovascular comorbidities and risk factors are associated with significant morbidity and mortality in hospitalized COVID-19 patients.
- Findings highlight the importance of managing cardiovascular health in COVID-19 patients.
Background:
The coronavirus disease 2019 (COVID-19) pandemic has led to a public health crisis. Only limited data are available on the characteristics and outcomes of patients hospitalized for COVID-19 in France.
Aims:
To investigate the characteristics, cardiovascular complications and outcomes of patients hospitalized for COVID-19 in France.
Methods:
The Critical COVID-19 France (CCF) study is a French nationwide study including all consecutive adults with a diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection hospitalized in 24 centres between 26 February and 20 April 2020. Patients admitted directly to intensive care were excluded. Clinical, biological and imaging parameters were systematically collected at hospital admission. The primary outcome was in-hospital death.
Results:
Of 2878 patients included (mean±SD age 66.6±17.0 years, 57.8% men), 360 (12.5%) died in the hospital setting, of which 7 (20.7%) were transferred to intensive care before death. The majority of patients had at least one (72.6%) or two (41.6%) cardiovascular risk factors, mostly hypertension (50.8%), obesity (30.3%), dyslipidaemia (28.0%) and diabetes (23.7%). In multivariable analysis, older age (hazard ratio [HR] 1.05, 95% confidence interval [CI] 1.03-1.06; P<0.001), male sex (HR 1.69, 95% CI 1.11-2.57; P=0.01), diabetes (HR 1.72, 95% CI 1.12-2.63; P=0.01), chronic kidney failure (HR 1.57, 95% CI 1.02-2.41; P=0.04), elevated troponin (HR 1.66, 95% CI 1.11-2.49; P=0.01), elevated B-type natriuretic peptide or N-terminal pro-B-type natriuretic peptide (HR 1.69, 95% CI 1.0004-2.86; P=0.049) and quick Sequential Organ Failure Assessment score ≥2 (HR 1.71, 95% CI 1.12-2.60; P=0.01) were independently associated with in-hospital death.
Conclusions:
In this large nationwide cohort of patients hospitalized for COVID-19 in France, cardiovascular comorbidities and risk factors were associated with a substantial morbi-mortality burden.
Related Concept Videos
01:30Pneumonia III: Complications and Assessment
01:28Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
01:15Bioavailability Study Design: Healthy Subjects Versus Patients
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
01:20COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...