An efficient and general method for the synthesis of stable isotope deuterium labeled phthalate esters
Zhongjie Xu1,2, Cheng Zhao2, Wen Sun2
1State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, China.
Abstract:
An efficient and general synthetic route of deuterium-labeled phthalate esters is described with high isotopic enrichment and excellent chemical purities using inexpensive and readily available o-xylene-D10 as labeled starting material. The structures and isotope-abundance were confirmed via 1 H NMR and mass spectrometry. These deuterium labeled phthalate esters can be used as analytical reference standards for the detection of plasticizer residues in soil, water, food, plastic products, etc.
More Related Videos
Related Concept Videos
Alkylation of β-Diester Enolates: Malonic Ester Synthesis
Carboxylic Acids to Methylesters: Alkylation using Diazomethane
¹H NMR of Labile Protons: Deuterium (²H) Substitution
Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis
Esters to β-Ketoesters: Claisen Condensation Mechanism


