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Updated: Nov 1, 2025

Three-Dimensional Culture of Murine Colonic Crypts to Study Intestinal Stem Cell Function Ex Vivo
Published on: October 11, 2022
Claudin14 promotes colorectal cancer progression via the PI3K/AKT/mTOR pathway
Tian-Yu Qiao1, Zi-Ming Yuan1, Tian-Yi Ma1
1Department of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Abstract:
Colorectal cancer is the third leading cancer in the world in terms of incidence and mortality. The role of differentially expressed Claudin-14 (CLDN14) in CRC has not been reported. We observed that CLDN14 was associated with the progression of CRC. Our functional studies have shown that CLDN14 promoted the proliferation of CRC cells. In addition, CLDN14 also increased the migration and invasion of CRC cells. In vivo experiments also showed that CLDN14 promoted the growth of colorectal cancer via the PI3K/AKT/mTOR. In summary, our research suggests that CLDN14 promotes the progression of colorectal cancer. Our findings may provide new strategies for clinical management and patient prognosis of CRC.
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