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'Rollover' abdominal paracentesis versus standard technique: protocol of a crossover randomized comparative trial

Vishal Sharma1, Daya Krishna Jha1, Manish Rohilla2

  • 1Department of Gastroenterology, Postgraduate Institute of Medical Education & Research, Chandigarh, 160012, India.

Future Oncology (London, England)
|June 22, 2021
PubMed

Keywords:
laparoscopymalignant ascitesperitoneal neoplasmperitoneal tuberculosistuberculous peritonitis

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Body:Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
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Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
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