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Updated: Jun 17, 2026
Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum
Published on: February 15, 2015
A double-blind randomized controlled trial combining cognitive training (CoRe) and neurostimulation (tDCS) in the
Claudia Rodella1, Sara Bernini2, Silvia Panzarasa3
1Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. claudia.rodella@gmail.com.
Background:
The prevalence of neurodegenerative diseases is expected to increase over the next years, therefore, new methods able to prevent and delay cognitive decline are needed.
Aims:
To evaluate the effectiveness of a combined treatment protocol associating a computerized cognitive training (CoRe) with anodal transcranial direct current stimulation (tDCS).
Methods:
In this randomized controlled trial, 33 patients in the early stage of cognitive impairment were assigned to the experimental group (CoRE + real tDCS) or control group (CoRE + sham tDCS). In each group, the intervention lasted 3 consecutive weeks (4 sessions/week). A neuropsychological assessment was administered at baseline (T0), post-intervention (T1) and 6-months later (T2).
Results:
The CoRE + real tDCS group only improved in working memory and attention/processing speed at both T1 and T2. It reported a stable MMSE score at T2, while the CoRE + sham tDCS group worsened. Age, mood, and T0 MMSE score resulted to play a role in predicting treatment effects.
Conclusion:
Combined multi-domain interventions may contribute to preventing or delaying disease progression.
Trial Registration:
Trial registration number (ClinicalTrials.gov): NCT04118686.
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