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Inhibition of human leukocyte 5-lipoxygenase by 15-HPETE and related eicosanoids
J R Cashman1, C Lambert, E Sigal
1Department of Pharmaceutical Chemistry and Liver Center, University of California, San Francisco 94115.
Biochemical and Biophysical Research Communications
|August 30, 1988
Abstract:
The inhibition of human leukocyte 5-lipoxygenase by 15-hydroperoxyeicosatetraenoic acid and its chemical or enzymatic rearrangement products was investigated. 15-Hydroperoxyeicosatetraenoic acid was the most potent inhibitor tested. The inhibition was found to be time dependent and is not due to chemical or enzymatic decomposition products nor metabolism of 15-hydroperoxyeicosatetraenoic acid to 5,15-dihydroperoxyeicosatetraenoic acid.