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Hypersensitivity reactions to biologicals: An EAACI position paper
Sevim Bavbek1, Mauro Pagani2, Emilio Alvarez-Cuesta3
1Division of Immunology and Allergy, Department of Chest Diseases, School of Medicine, Ankara University, Ankara, Turkey.
Allergy
|June 22, 2021
Summary
Biologicals, crucial for treating cancer and immune diseases, frequently cause hypersensitivity reactions (HSRs). This paper offers evidence-based guidance for diagnosing and managing these potentially severe HSRs to biological therapies.
Area of Science:
- Immunology
- Pharmacology
- Oncology
Background:
- Biological therapies are increasingly used for oncological, immunological, and inflammatory conditions.
- Personalized Precision Medicine has accelerated the development and use of biologicals.
- Biologicals are now a common cause of hypersensitivity reactions (HSRs), which can be severe.
Purpose of the Study:
- To provide evidence-based recommendations for the diagnosis and management of HSRs to biologicals.
- To define unmet needs in the field of HSRs to biologicals to guide future research.
Main Methods:
- This Position Paper synthesizes current evidence.
- Expert consensus and literature review inform the recommendations.
Main Results:
- HSRs to biologicals can occur upon first or repeated exposure.
- Mechanisms underlying HSRs to biologicals are not fully understood.
- Optimal management strategies for HSRs to biologicals are still debated.
Conclusions:
- Clear diagnostic and management guidelines are needed for HSRs to biologicals.
- Further research is required to elucidate HSR mechanisms and improve patient outcomes.
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