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Long non-coding RNAs: A view to kill ovarian cancer

Alexey V Zamaraev1, Pavel I Volik1, Gennady T Sukhikh2

  • 1Faculty of Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia.

Biochimica Et Biophysica Acta. Reviews on Cancer
|June 22, 2021
PubMed

Insights

Long non-coding RNAs (lncRNAs) play a key role in ovarian cancer progression. Understanding lncRNA functions in cancer hallmarks is crucial for developing new diagnostic and therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in cancer.
  • lncRNAs can modulate gene expression and protein activity, influencing tumor development.

Purpose of the Study:

  • To review the role of tumor-associated lncRNAs in ovarian cancer.
  • To discuss lncRNA contributions to cancer hallmarks like proliferation, metastasis, and immune evasion.
  • To explore the clinical significance of lncRNAs for ovarian cancer diagnosis, prognosis, and therapy.

Main Methods:

  • Literature review and synthesis of existing research on lncRNAs in ovarian cancer.

Main Results:

  • lncRNAs are implicated in key ovarian cancer hallmarks, including intense proliferation, resistance to cell death, altered metabolism, invasion, metastasis, and immune evasion.
  • Aberrant lncRNA expression or mutations are linked to dysregulation of cellular processes in ovarian cancer.

Conclusions:

  • Tumor-associated lncRNAs represent promising biomarkers and therapeutic targets for ovarian cancer.
  • Further research into lncRNA mechanisms can advance ovarian cancer diagnostics and treatment strategies.
Keywords:
Cancer hallmarksLncRNAsOvarian cancerPrognosis, targeted therapy

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