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Updated: Nov 1, 2025
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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Published on: May 24, 2024
Cyclotron-produced 68Ga from enriched 68Zn foils
Jonathan Siikanen1, Emma Jussing2, Stefan Milton2
1Karolinska University Hospital, Department of Medical Radiation Physics and Nuclear Medicine, Eugeniavägen 3, SE- 171 76, Stockholm, Sweden; Karolinska Institutet, Department of Oncology and Pathology, Akademiska stråket 1, SE-171 64, Stockholm, Sweden.
Abstract:
The growing need and limited availability of generator produced 68Ga (T1/2 = 68 min) for PET has provided the impetus for alternative, high output, 68Ga production routes such as charge particle activation of enriched 68Zn using PET cyclotrons. The work presents a rapid production method for clinically useful 68Ga for radiolabeling. The focus is also to expand the production capacity of cyclotron solid target-produced 68Ga over generator produced and liquid solutions targets by using enriched 68Zn-foils that minimizes target preparation.
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