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Updated: Nov 1, 2025
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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Published on: May 24, 2024
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Cyclotron-produced 68Ga from enriched 68Zn foils
Jonathan Siikanen1, Emma Jussing2, Stefan Milton2
1Karolinska University Hospital, Department of Medical Radiation Physics and Nuclear Medicine, Eugeniavägen 3, SE- 171 76, Stockholm, Sweden; Karolinska Institutet, Department of Oncology and Pathology, Akademiska stråket 1, SE-171 64, Stockholm, Sweden.
Summary
High-yield Gallium-68 (68Ga) production for PET imaging is now possible using enriched 68Zn-foils and PET cyclotrons. This method offers a rapid, scalable alternative to generator-produced 68Ga, minimizing target preparation.
Area of Science:
- Nuclear Chemistry
- Radiopharmaceutical Chemistry
- Medical Imaging
Background:
- Limited availability of generator-produced Gallium-68 (68Ga) for Positron Emission Tomography (PET).
- Growing demand for 68Ga necessitates alternative, high-output production methods.
- Need for scalable and efficient 68Ga production for clinical radiolabeling.
Purpose of the Study:
- To present a rapid production method for clinically useful 68Ga.
- To expand the production capacity of cyclotron-produced 68Ga.
- To utilize enriched 68Zn-foils for efficient 68Ga generation.
Main Methods:
- Charge particle activation of enriched 68Zn using PET cyclotrons.
- Solid target preparation using enriched 68Zn-foils.
- Rapid production of 68Ga for radiolabeling.
Main Results:
- Successful rapid production of clinically useful 68Ga.
- Demonstrated high-output potential of cyclotron-based 68Ga production.
- Minimized target preparation through the use of enriched 68Zn-foils.
Conclusions:
- Enriched 68Zn-foil activation in PET cyclotrons is an effective method for high-yield 68Ga production.
- This approach offers a scalable and efficient alternative to generator-based 68Ga.
- The method simplifies target preparation, enhancing overall production capacity.
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