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The clinical features and prognosis of 31 HIV-infected diffuse large B-cell lymphoma cases

Yun Lian1, Jiayu Huang2, Huihui Zhao1

  • 1Department of Hematology, Nanjing Second Hospital, Nanjing University of Chinese Medicine, Nanjing, China.

Science Progress
|June 23, 2021
PubMed

Insights

Human immunodeficiency virus (HIV)-infected diffuse large B-cell lymphoma (DLBCL) patients present with high-risk factors and mortality. Hepatitis C Virus (HCV) coinfection may worsen survival outcomes in these patients.

Area of Science:

  • Oncology
  • Infectious Diseases
  • Hematology

Background:

  • Diffuse large B-cell lymphoma (DLBCL) in human immunodeficiency virus (HIV)-infected individuals presents unique clinical challenges.
  • Understanding the characteristics and prognosis of HIV-infected DLBCL is crucial for improving patient outcomes.

Purpose of the Study:

  • To describe the clinical features and survival prognosis of HIV-infected DLBCL patients.
  • To identify factors associated with overall survival in this cohort.

Main Methods:

  • Retrospective enrollment of 31 newly diagnosed HIV-infected DLBCL patients between 2009 and 2019.
  • Analysis of patient demographics, CD4+ counts, International Prognostic Index (IPI) scores, treatments (highly active antiretroviral therapy and chemotherapy), and coinfections.
  • Univariate survival analysis to determine prognostic factors.

Main Results:

  • The median age was 47 years, with 87.1% males and a mean CD4+ count of 150.72/μl.
  • A high proportion (77.4%) had medium-high risk IPI scores, and the mortality rate was 58.1%.
  • Hepatitis C Virus (HCV) infection and standard chemotherapy were associated with overall survival (OS).

Conclusions:

  • HIV-infected DLBCL patients exhibit high-risk disease characteristics and significant mortality.
  • HCV coinfection may be linked to poorer OS.
  • Early diagnosis and standardized treatment approaches are recommended to enhance survival.

Keywords:
Human immunodeficiency virus-infecteddiffuse large B-cell lymphomaprognostic factorsretrospective studies

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