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Association between postnatal weight gain and need for treatment in retinopathy of prematurity

Ma José Cabañas Poy1, José Bruno Montoro Ronsano1, Félix Castillo Salinas2

  • 1Servicio de Farmacia, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|June 23, 2021
PubMed

Insights

Gestational age and early postnatal weight gain are key factors in determining the need for retinopathy of prematurity (ROP) treatment in premature infants. Birth weight was not a significant predictor.

Area of Science:

  • Neonatal Medicine
  • Ophthalmology
  • Pediatric Growth and Development

Background:

  • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
  • Gestational age (GA) and birth weight are known risk factors for ROP development.
  • The role of early postnatal weight gain in ROP treatment needs is less understood.

Purpose of the Study:

  • To investigate the association between gestational age (GA) and birth weight with ROP development.
  • To determine the link between postnatal weight gain in the first 6 weeks and the requirement for ROP treatment.
  • To identify predictive factors for ROP treatment necessity.

Main Methods:

  • Retrospective observational study including premature infants who underwent ophthalmoscopy.
  • Data collected included obstetric and birth characteristics, comorbidities, GA, birth weight, and weekly weights for the first 6 weeks.
  • Statistical analysis to identify significant predictors of ROP treatment.

Main Results:

  • Ninety premature infants were studied with a mean GA of 26.87 weeks and mean birth weight of 884.29g.
  • 41.1% of infants were diagnosed with ROP, and 10% required treatment.
  • Gestational age (p=0.018) and weight at 6 weeks (p=0.021) were significant predictors for ROP treatment; birth weight was not (p=0.361).

Conclusions:

  • Gestational age and postnatal weight gain during the first 6 weeks are significantly associated with the need for ROP treatment.
  • Postnatal weight gain at 6 weeks is a predictive factor for ROP treatment.
  • Sex and birth weight were not found to be significant predictors for ROP treatment necessity.
Abstract

Keywords:
Retinopathy of prematuritytreatmentweight gain

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