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[Centrally Mediated Abdominal Pain Syndrome]
1Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine, Changwon, Korea.
Centrally mediated abdominal pain syndrome (CAPS) affects 0.5-2.1% of the population, predominantly females. Central nervous system sensitization is key, with new treatments showing promise.
Area of Science:
- Gastroenterology
- Neuroscience
- Pain Medicine
Background:
- Centrally mediated abdominal pain syndrome (CAPS), also known as functional abdominal pain syndrome, has a prevalence of 0.5%–2.1%.
- The exact pathogenesis of CAPS remains under investigation.
- A female predominance is observed in CAPS patients.
Purpose of the Study:
- To review the current understanding of CAPS pathogenesis.
- To highlight diagnostic criteria and emerging therapeutic strategies.
- To emphasize the role of central nervous system mechanisms.
Main Methods:
- Review of existing literature on CAPS.
- Analysis of diagnostic criteria (Rome IV).
- Evaluation of current treatment trials and patient-physician relationship impacts.
Main Results:
- Central nervous system sensitization and disinhibition of pain pathways are significant factors in CAPS.
- Peripheral afferent neuronal excitability may play a lesser role.
- New treatment trials and improved patient-physician relationships demonstrate positive outcomes.
Conclusions:
- CAPS diagnosis relies on the Rome IV criteria, focusing on gastrointestinal symptom clusters.
- Central mechanisms are crucial in CAPS pathophysiology.
- Ongoing research and therapeutic advancements offer hope for improved patient management.
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