Eosinophilic Colitis that Presented with Subepithelial Tumor-like Lesions

Area of Science:

• Gastroenterology
• Pathology

Background:

• Eosinophilic colitis is a rare gastrointestinal disorder characterized by eosinophil infiltration of the colon wall.
• Its epidemiology and pathophysiology are not well-defined, but hypersensitivity responses are suspected contributors.
• Diagnosis is typically made by exclusion, after other causes of eosinophilic infiltration are ruled out.

Observation:

• A 41-year-old male presented with abdominal pain and loose stools.
• Endoscopic examination revealed subepithelial tumor-like lesions in the colon, an atypical presentation.
• Colon biopsy confirmed eosinophilic infiltration in the lamina propria.

Findings:

• The case highlights eosinophilic colitis presenting as subepithelial tumor-like lesions.
• Colon biopsy confirmed eosinophilic infiltration, supporting the diagnosis.
• The patient had no prior history of allergies or significant medical conditions.

Implications:

• This case expands the known endoscopic spectrum of eosinophilic colitis.
• It underscores the importance of considering eosinophilic colitis in unexplained gastrointestinal symptoms, even with unusual findings.
• Steroid therapy demonstrated efficacy in managing this rare condition.