Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

670
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
670
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

5.3K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
5.3K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

684
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
684
Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

521
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
521
Antibiotic Selection00:57

Antibiotic Selection

56.9K
Overview
56.9K
Methods for Controlling Microbial Growth01:29

Methods for Controlling Microbial Growth

1.1K
Microbial growth control refers to various methods employed to inhibit, reduce, or eliminate microorganisms to ensure safety and hygiene across different settings. These methods are categorized based on the target environment and the level of microbial control required.Biocides are versatile agents designed to control microorganisms by either inhibiting their growth or outright killing them. These agents work through various physical, chemical, mechanical, or biological mechanisms. The...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-Term Mortality among Hospitalized Adults with Sepsis in Uganda: A Prospective Cohort Study.

The American journal of tropical medicine and hygiene·2026
Same author

Spray dried plasma manufactured from apheresis and whole blood derived plasma.

Transfusion·2026
Same author

Clinical profiles of patients with antibiotic-resistant infections at select tertiary hospitals in Uganda: a retrospective study of clinical records.

BMC infectious diseases·2026
Same author

Prospective Methodology Results in Higher Rates of Reported Complications Following Pediatric ACL Reconstruction.

Journal of pediatric orthopedics·2026
Same author

Evaluating the appropriateness of prescribing antibiotics among persons with HIV (PWH) in an Urban HIV outpatient clinic in Uganda.

Antimicrobial resistance and infection control·2026
Same author

Integration of specialised mental health services in an HIV clinic in a low resource setting.

BMJ open quality·2026
Same journal

Waterborne diseases and climate change.

Nature reviews. Microbiology·2026
Same journal

Climate adaptation and biodiversity shape West Nile virus risk in cities.

Nature reviews. Microbiology·2026
Same journal

Climate factors and evolution drive cholera surges in Dhaka.

Nature reviews. Microbiology·2026
Same journal

Climate change boosts Salmonella antimicrobial resistance.

Nature reviews. Microbiology·2026
Same journal

Reframing risk assessment for malaria elimination in a changing climate.

Nature reviews. Microbiology·2026
Same journal

Bacterial vesicles protect the membrane during polymyxin stress.

Nature reviews. Microbiology·2026
See all related articles

Related Experiment Video

Updated: Nov 1, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

13.1K

Optimizing antimicrobial use: challenges, advances and opportunities.

Timothy M Rawson1,2, Richard C Wilson1,2, Danny O'Hare2,3

  • 1National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London, UK.

Nature Reviews. Microbiology
|June 23, 2021
PubMed
Summary
This summary is machine-generated.

Optimizing antimicrobial dosing requires advanced methods to manage patient variability. Real-time monitoring and adaptive control systems promise improved outcomes and reduced drug resistance.

More Related Videos

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

22.4K
Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
12:03

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

26.8K

Related Experiment Videos

Last Updated: Nov 1, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

13.1K
Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

22.4K
Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
12:03

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

26.8K

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Biomedical Engineering

Background:

  • Optimal antimicrobial dosing balances efficacy with toxicity and resistance.
  • Pharmacokinetic variability, influenced by patient factors, impacts treatment success.
  • Current dosing strategies inadequately address residual inter-individual variability.

Purpose of the Study:

  • To review challenges in implementing antimicrobial dose optimization.
  • To highlight novel solutions for real-time antimicrobial dosing adjustments.
  • To emphasize the importance of precision dosing for patient outcomes and antimicrobial stewardship.

Main Methods:

  • Review of current antimicrobial dose optimization strategies.
  • Exploration of novel monitoring and control systems.
  • Discussion of challenges and future directions in precision dosing.

Main Results:

  • Existing methods for antimicrobial dose optimization have limitations.
  • Biosensor-based real-time therapeutic drug monitoring offers a potential solution.
  • Computer-controlled, closed-loop systems represent a novel approach to adaptive dosing.

Conclusions:

  • Precision antimicrobial dosing can enhance patient outcomes.
  • Advanced monitoring and control systems are crucial for managing variability.
  • Effective dose optimization is vital for antimicrobial stewardship and combating resistance.