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Updated: Nov 1, 2025

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
Published on: January 26, 2016
Engineered Cyclotides with Potent Broad in Vitro and in Vivo Antimicrobial Activity
Rajasekaran Ganesan1, Mansour A Dughbaj1,2, Lisa Ramirez3
1Department of Pharmacology and Pharmaceutical Sciences School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA.
Abstract:
The search for novel antimicrobial agents to combat microbial pathogens is intensifying in response to the rapid development of drug resistance to current antibiotic therapeutics. Respiratory failure and septicemia are the leading causes of mortality among hospitalized patients. Here, the development of a novel engineered cyclotide with effective broad-spectrum antibacterial activity against several ESKAPE bacterial strains and clinical isolates is reported. The most active antibacterial cyclotide was extremely stable in serum, showed little hemolytic activity, and provided protection in vivo in a murine model of P. aeruginosa peritonitis. These results highlight the potential of the cyclotide scaffold for the development of novel antimicrobial therapeutic leads for the treatment of bacteremia.
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