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Clinical Trials of COVID-19 Therapies Should Account for Diabetes and Hyperglycemia

David C Klonoff1, Jordan Messler2, Timothy Valk3

  • 1Mills-Peninsula Medical Center, San Mateo, CA, USA.

Journal of Diabetes Science and Technology
|June 23, 2021
PubMed

Insights

Patients with diabetes or hyperglycemia face higher COVID-19 complication risks. Stratifying patients by these conditions in clinical trials can improve antiviral treatment development for this vulnerable group.

Area of Science:

  • Infectious Diseases
  • Endocrinology
  • Metabolic Disorders

Background:

  • Coronavirus Disease 2019 (COVID-19) complications are more frequent in hospitalized patients with diabetes or hyperglycemia.
  • Overlapping pathophysiological features link COVID-19, diabetes, and glucose dysregulation, contributing to increased infection risk.

Purpose of the Study:

  • To propose stratifying COVID-19 patients by diabetes or hyperglycemia status in clinical trials.
  • To facilitate the development of antiviral treatments specifically beneficial for patients with these metabolic conditions.

Main Methods:

  • The study is a conceptual proposal for clinical trial design.
  • It suggests evaluating treatment effects in stratified patient groups.

Main Results:

  • Not applicable in this conceptual study.
  • The proposed stratification aims to identify differential treatment effects.

Conclusions:

  • Stratifying COVID-19 patients with diabetes or hyperglycemia in clinical trials is crucial.
  • This approach will optimize antiviral therapy development for a significant patient subset.

Keywords:
COVID-19antiviralclinical trialdiabeteshospitalhyperglycemia

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