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Published on: June 12, 2020
ELECTROCARDIOGRAPHIC CHANGES IN NEWBORNS FROM MOTHERS WITH METABOLIC SYNDROME
Valeriy I Pokhylko1, Olena M Kovalova1, Svitlana M Tsvirenko1
1POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE.
Insights
Infants born to mothers with metabolic syndrome show abnormal electrocardiogram (ECG) findings, indicating potential cardiovascular risks. These early cardiac dysfunction signs may predict future heart disease in children.
Area of Science:
- Neonatal cardiology
- Perinatal medicine
- Maternal-fetal medicine
Background:
- Maternal metabolic syndrome poses risks to fetal development.
- Cardiovascular health in newborns requires careful monitoring.
- Early detection of cardiac dysfunction is crucial for long-term outcomes.
Purpose of the Study:
- To analyze electrocardiographic (ECG) parameters in newborns of mothers with metabolic syndrome.
- To identify specific ECG changes associated with maternal metabolic syndrome.
- To evaluate ECG findings as early indicators of cardiovascular risk in neonates.
Main Methods:
- Prospective cohort study of 125 newborns.
- Included anthropometric, clinical, and laboratory indicators, with a focus on ECG parameters.
- Compared newborns from mothers with metabolic syndrome (n=40) to controls (n=85, term and preterm).
Main Results:
- Newborns of mothers with metabolic syndrome exhibited abnormal depolarization on ECG, including QRS widening, impaired conduction, T-wave changes, and prolonged QT interval.
- Risk factors for QT prolongation included maternal cardiovascular disease, lipid disorders, birth asphyxia, electrolyte imbalances, high birth weight for gestational age, neonatal hypertension, and artificial feeding.
- Significant associations were found between maternal metabolic syndrome and specific ECG abnormalities (p<0.001).
Conclusions:
- Maternal metabolic syndrome significantly impacts the cardiovascular system of newborns.
- Detected ECG abnormalities serve as early, integrated indicators of metabolic syndrome and potential cardiovascular disease in children.
- This study highlights the importance of ECG monitoring in neonates exposed to maternal metabolic syndrome.
Objective:
The aim: Analysis of electrocardiographic parameters in newborns from mothers with metabolic syndrome.
Patients And Methods:
Materials and methods: We conducted a prospective cohort trial of 125 newborns, which included the study of their anthropometric, clinical and laboratory indicators and, in particular, ECG parameters. The main group consisted of 40 children, born from mothers with diagnosed metabolic syndrome, the comparison group included 2 subgroups: 28 term newborn and 57 preterm, from mothers without metabolic syndrome.
Results:
Results: In newborns from mothers with metabolic syndrome on a fragmentary ECG we revealed abnormal depolarization, manifested by changes in the ventricular complex -QRS expansion (p<0.001), impaired conduction (p = 0.004), changes of T wave (p<0.001) and prolonged QT interval (p<0.001). There are such risk factors for QT prolongation in neonates: disease cardiovascular system and disorders of lipid metabolism in mother, asphyxia at birth and electrolyte disorders (hypernatremia OR 0.97), weight too high to gestational age at birth in newborn (OR 2.97), increased blood pressure in the neonatal period (OR 1.07), artificial feeding (OR 3.01).
Conclusion:
Conclusions: Metabolic syndrome in women during pregnancy has a pronounced effect on the cardiovascular system of the newborn. The detected signs of cardiac dysfunction on the ECG can serve as early integrated indicators of metabolic syndrome and cardiovascular disease in children.
