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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
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LncRNAs and Available Databases.

Sara Napoli1

  • 1Faculty of Biomedical Sciences, Institute of Oncology Research, USI, Bellinzona, Switzerland. sara.napoli@ior.usi.ch.

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|June 23, 2021
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Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) regulate gene expression throughout the RNA lifecycle. This review organizes web resources and tools to aid researchers in studying lncRNA functions and interactions.

Keywords:
DatabaseDisease associationIn silico predictionProtein interactionlncRNAmiRNA interaction

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Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • Long noncoding RNAs (lncRNAs) are key regulators in gene expression, impacting transcription, RNA stability, and translation.
  • lncRNAs represent a diverse group of molecules with varied origins, interaction networks, and biological roles.
  • The scientific community increasingly relies on accessible web-based databases for lncRNA information.

Purpose of the Study:

  • To review and organize prominent web resources for long noncoding RNA research.
  • To provide a compendium of tools for interrogating lncRNAs before in-depth study.
  • To facilitate easier access to public lncRNA data for researchers.

Main Methods:

  • Literature review of existing lncRNA databases and bioinformatics tools.
  • Categorization of resources based on their utility in lncRNA research.
  • Synthesis of information to create a curated compendium.

Main Results:

  • Identification of key databases and tools for lncRNA analysis.
  • Organization of these resources into a user-friendly format.
  • Highlighting the heterogeneity and broad regulatory roles of lncRNAs.

Conclusions:

  • Accessible databases and tools are crucial for advancing lncRNA research.
  • This review serves as a guide for researchers navigating the landscape of lncRNA resources.
  • Efficiently utilizing available tools can accelerate the study of lncRNA mechanisms and functions.