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Related Experiment Video

Updated: Nov 1, 2025

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
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Fluid metabolic pathways after subarachnoid hemorrhage.

Jiru Zhou1,2,3, Peiwen Guo2,3, Zongduo Guo1

  • 1Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Journal of Neurochemistry
|June 23, 2021
PubMed
Summary

Aneurysmal subarachnoid hemorrhage disrupts brain energy metabolism. This review explores fluid circulation and glymphatic system dysfunction, proposing new therapeutic targets for this critical neurological condition.

Keywords:
cerebrospinal fluid circulationcerebrum microdialysisenergy metabolismglymphatic systemmicrocirculation disturbancesubarachnoid hemorrhage

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Area of Science:

  • Neurology
  • Cerebrovascular Diseases
  • Neuroscience

Background:

  • Aneurysmal subarachnoid hemorrhage (aSAH) is a severe condition with high mortality and morbidity.
  • Current treatments for aSAH have not significantly improved patient outcomes, highlighting the need for deeper understanding of its complex pathogenesis.
  • Focus has been on early brain injury and delayed cerebral ischemia, but the disruption of central nervous system energy metabolism is critical.

Purpose of the Study:

  • To review the fluid metabolic pathways in the central nervous system following aneurysmal subarachnoid hemorrhage.
  • To discuss the dysfunction of blood circulation, cerebrospinal fluid circulation, and the glymphatic system in aSAH.
  • To propose a hypothesis on the metabolic disorder mechanisms and identify potential therapeutic targets for aSAH.

Main Methods:

  • Literature review focusing on fluid metabolism in the central nervous system after aSAH.
  • Analysis of pathophysiological processes including blood and CSF circulation, and glymphatic system function.
  • Synthesis of current knowledge to propose a novel hypothesis on metabolic disorders.

Main Results:

  • Aneurysmal subarachnoid hemorrhage leads to the destruction of energy metabolism balance in the nervous system.
  • Dysfunction in blood circulation, cerebrospinal fluid circulation, and the glymphatic system are key features of aSAH progression.
  • The review identifies critical metabolic disruptions contributing to poor neurological function.

Conclusions:

  • Metabolic disorders, particularly in fluid circulation and the glymphatic system, are central to aSAH pathogenesis.
  • Understanding these metabolic disruptions offers new avenues for therapeutic interventions.
  • Targeting metabolic pathways presents a promising strategy to improve outcomes for aSAH patients.