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SARS-CoV-2 Variants and Vaccines.

Philip R Krause1, Thomas R Fleming1, Ira M Longini1

  • 1From the Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD (P.R.K., M.G.); the Department of Biostatistics, University of Washington, Seattle (T.R.F.); the Department of Biostatistics, University of Florida, Gainesville (I.M.L.); the Nuffield Department of Population Health, University of Oxford (R.P., V.B.), and the Oxford Vaccine Group, Department of Paediatrics, University of Oxford and National Institute for Health Research Oxford Biomedical Research Centre (M.D.S.), Oxford, and the Global Health Programme, Chatham House (D.L.H.), and the Coalition for Epidemic Preparedness Innovations (J.P.C.), London - all in the United Kingdom; the Howard College School of Law, University of KwaZulu-Natal, Durban (J.A.S.), and the Wits Reproductive Health and HIV Institute, Johannesburg (H.R.) - both in South Africa; the Dalla Lana School of Public Health, University of Toronto, Toronto (J.A.S.); the Clalit Research Institute, Innovation Division, Clalit Health Services, Tel Aviv, Israel (R.D.B.); the Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany (C.M.-F.); the World Health Organization Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia (K.S.); and the World Health Organization, Geneva (S.B., A.-M.R., R.G., M.D.V.K., S.S., M.J.R., A.-M.H.-R.).

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This summary is machine-generated.

Emerging coronavirus disease 2019 (Covid-19) variants may resist current vaccines. A timely, science-based global response, including public health measures and vaccination, is crucial to manage increased transmissibility or virulence.

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Area of Science:

  • Virology
  • Immunology
  • Epidemiology

Background:

  • Current vaccines protect against coronavirus disease 2019 (Covid-19).
  • Viral evolution poses a risk of immune escape and increased pathogen transmissibility or virulence.
  • The emergence of variants of concern necessitates adaptive public health strategies.

Purpose of the Study:

  • To highlight the potential threat of viral variants to Covid-19 vaccine efficacy.
  • To emphasize the need for enhanced public health measures and vaccination programs in response to evolving viral threats.
  • To advocate for a timely and science-based global response to the Covid-19 pandemic.

Main Methods:

  • This study is a review of current scientific literature on viral variant emergence and its implications.
  • Analysis of epidemiological data and immunological studies related to Covid-19 vaccine effectiveness.
  • Assessment of public health strategies in the context of viral evolution.

Main Results:

  • Viral variants may develop resistance to existing Covid-19 immunity.
  • Increased transmissibility or virulence in variants of concern could necessitate modified interventions.
  • The effectiveness of current vaccination programs may be challenged by emerging viral strains.

Conclusions:

  • Continuous monitoring of viral evolution is essential.
  • Adaptable and robust public health measures are critical for pandemic control.
  • A coordinated, science-driven global response is paramount to address the ongoing Covid-19 threat.