Related Experiment Video
Updated: Nov 1, 2025
Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens
Published on: February 24, 2021
Structural Phylogeny of Different Allergens May Reveal Common Epitopic Footprint
Anubhab Laha1, Rajib Bandopadhyay1, Anindya Sundar Panja2
1UGC Centre for Advanced Study, Department of Botany, The University of Burdwan, Golapbag, Burdwan - 713104, West Bengal, India.
Background:
The incidence of allergy has been increasing at an alarming rate over the last few decades.
Objective:
Our present study aims to find out the structurally homologous motifs present in different proteinaceous allergens.
Methods:
Significant number of protein sequences and their corresponding structures of various pollen, fungal, bacterial, and food allergens were retrieved and the sequence and structural identity were analyzed.
Results:
Intra- and inter-sequence along with their structural analysis of the proteinaceous allergens revealed that no significant relationships exist among them. A few, but not the negligible number of high structural similarities, were observed within different groups of allergens from fungus, angiosperms, and animals (Aves and Mammalia).
Conclusion:
Our in silico study on thirty-six different allergens showed a significant level of structural similarities among themselves, regardless of their sequences.
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