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Updated: Nov 1, 2025

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

Published on: March 30, 2020

Cell-based Therapy for Ocular Disorders: A Promising Frontier.

Milad Ahani-Nahayati^1,2, Vahid Niazi¹, Alireza Moradi³

¹Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.

Current Stem Cell Research & Therapy

|June 23, 2021

Summary

Stem cell therapies offer promising treatments for blinding ocular disorders, addressing limitations of current approaches. Research highlights the safety and efficacy of various stem cells, including Retinal Pigment Epithelial cells, for conditions like Age-related Macular Degeneration.

Keywords:

Ocular diseases cell-based therapy multipotent stem cells pluripotent stem cells regenerative medicine stem cell

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Author Spotlight: Advancing Vision Restoration - Stem Cell-Based Therapy for Retinal Diseases

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Published on: October 6, 2023

Area of Science:

Ophthalmology
Regenerative Medicine
Stem Cell Biology

Background:

Ocular disorders significantly impair quality of life and can lead to irreversible blindness.
Current treatments for visual impairment have limitations and do not prevent disease progression.
Stem cells present a promising avenue for regenerative medicine in treating eye diseases.

Purpose of the Study:

To review the pathogenesis of major ocular disorders.
To highlight recent advancements in stem cell-based therapies for eye conditions.
To focus on in vivo studies from the last decade.

Main Methods:

Review of scientific literature on ocular disease pathogenesis.
Analysis of preclinical and clinical studies involving various stem cell types (MSC, NSC, ESC/iPSC, Müller glia, ciliary epithelia, RPE).
Focus on in vivo investigations and outcomes.

Main Results:

Mesenchymal Stem/Stromal Cells (MSC), Neural Stem Cells (NSCs), and pluripotent stem cells (ESCs/iPSCs) show potential.
Retinal Pigment Epithelial (RPE) cell suspensions have been successfully used to treat Age-related Macular Degeneration (AMD).
Safety and efficacy data from preclinical models and human subjects are accumulating.

Conclusions:

Stem cell therapy is a rapidly advancing field for treating blinding eye diseases.
Further research and clinical translation are crucial for widespread application.
Targeted stem cell interventions hold significant promise for restoring vision.