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Related Experiment Video

Updated: Nov 1, 2025

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

Hyperbaric hyperoxemia as a risk factor for ventilator-acquired pneumonia?

Morgan Caplan¹, Thibault Duburcq¹, Anne-Sophie Moreau¹

¹Intensive Care Unit and Hyperbaric Center, Lille University Hospital, Lille, France.

|June 23, 2021

Summary

Hyperbaric oxygen therapy (HBOT) is not associated with an increased risk of ventilator-acquired pneumonia (VAP) in intensive care unit patients. Known VAP risk factors like reintubation and transport remain significant, independent of HBOT use.

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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS

Published on: April 7, 2021

Area of Science:

Critical Care Medicine
Pulmonology
Infectious Diseases

Background:

Ventilator-acquired pneumonia (VAP) is a significant cause of morbidity in Intensive Care Units (ICUs).
Hyperbaric oxygen therapy (HBOT) involves mechanical ventilation and may present unique risk factors, including hyperoxemia and patient transfers.

Purpose of the Study:

To evaluate the association between HBOT and the incidence of VAP in mechanically ventilated patients.

Main Methods:

A retrospective observational study was conducted in a 10-bed ICU from March 2017 to March 2018.
Included were patients on mechanical ventilation (MV) for over 48 hours, with VAP diagnosed via clinical and radiological criteria.
Data were collected from digital records, and risk factors were analyzed using univariate and multivariate methods.

Main Results:

Of 182 patients, 42 (23%) developed VAP. HBOT was administered to 124 (68%) patients.
VAP incidence was 34 per 1000 ventilator days. Significant VAP risk factors included immunosuppression, longer MV duration, extended hospital stay, reintubation, intra-hospital transport, paralytic agents, tracheotomy, and prone positioning.
HBOT use was not found to be associated with VAP occurrence. Independent VAP risk factors identified were reintubation, intra-hospital transport, and paralytic agent use.

Conclusions:

Established risk factors for VAP are present in the ICU population studied.
HBOT does not appear to be an additional risk factor for VAP in this patient group.
Further research is needed to elucidate the precise impact of HBOT on VAP development and the respiratory microbiome.