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Smooth Muscle Overexpression of PGC1α Attenuates Atherosclerosis in Rabbits

Zhe Wei1, Hoshun Chong2, Qixia Jiang3

  • 1Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), Institute of Artificial Intelligence Biomedicine, School of Life Sciences, Nanjing University, Jiangsu, China (Z.W., Y.T., J.X., H.W., Y.S., L.C., Jing Li, Y.Z., X.C., D.W., C.-Y.Z., X.J.).

Circulation Research
|June 24, 2021
PubMed

Keywords:
atherosclerosismetabolismrabbitssmooth muscle myocytes

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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