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Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

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Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human

Pranavi Garlapati1, Jinjie Ling2, Paul J Chiao1

  • 1Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

Cancer Cell International
|June 24, 2021
PubMed

Insights

Circular RNAs (circRNAs) are key regulators in cancer development. This review explores their roles in various cancers, offering insights into potential diagnostic biomarkers and therapeutic targets.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Circular RNAs (circRNAs) are increasingly recognized for their significant roles in diverse pathological processes, notably in cancer.
  • High-throughput RNA sequencing has revealed differential expression of numerous circRNAs across various cancer cell lines.
  • These circRNAs are implicated in regulating crucial cell signaling pathways through modulation of gene expression.

Purpose of the Study:

  • To elucidate the specific roles of circRNAs in different types of cancer.
  • To understand the molecular mechanisms by which circRNAs influence cellular components.
  • To highlight the potential of circRNAs as diagnostic and prognostic biomarkers and therapeutic targets in oncology.

Main Methods:

  • Review of literature on circRNA expression and function in cancer.
  • Analysis of high-throughput RNA sequencing data identifying differentially expressed circRNAs.
  • Discussion of proposed mechanisms of circRNA-mediated gene regulation.

Main Results:

  • Identification of various circRNAs dysregulated in different cancer types.
  • Elucidation of circRNA involvement in modulating key cancer-related signaling pathways.
  • Demonstration of circRNAs' capacity to upregulate or downregulate specific cellular components.

Conclusions:

  • Circular RNAs play critical roles in cancer pathogenesis.
  • Understanding circRNA functions and expression patterns is vital for cancer research.
  • CircRNAs represent promising candidates for novel cancer biomarkers and therapeutic strategies.
Keywords:
BiomarkersCircular RNAHuman cancerSignaling pathwaysmiRNA sponging

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