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Generalised eruptive histiocytosis preceded by systemic symptoms
Caitlyn N Myrdal1, Delaney B Stratton2, Tracy L Davis3
1Dermatology Division, The University of Arizona College of Medicine Tucson, Tucson, Arizona, USA cmyrdal@email.arizona.edu.
BMJ Case Reports
|June 24, 2021
Summary
Generalised eruptive histiocytosis, a rare skin condition, can present with systemic symptoms like fever and weight loss, not just skin lesions. Histology is key to diagnosis and ruling out other conditions.
Area of Science:
- Dermatology
- Pathology
Background:
- Generalised eruptive histiocytosis (GEH) is a rare histiocytic proliferative disorder.
- It typically manifests as indolent cutaneous eruptions.
Observation:
- A 73-year-old man presented with diffuse, asymptomatic papules.
- Prodromal symptoms included malaise, myalgias, fluctuating fever, chills, and weight loss.
Findings:
- Histological evaluation showed a non-Langerhans cell histiocytic dermal infiltrate.
- The infiltrate displayed spindle cell features, chronic inflammation, and was CD68 positive, S100 negative, and CD1a negative.
- Malignancy screening results were negative.
Implications:
- This case highlights an unusual presentation of generalized eruptive histiocytosis with systemic symptoms.
- Emphasizes the importance of histological examination for accurate diagnosis.
- Underscores the need for careful consideration of malignancy screening in atypical presentations.
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