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Updated: Nov 1, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Total Synthesis of Endolides A and B
Langlang Liu1,2, Yian Guo1, Qingchao Liu2
1Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Xili, Shenzhen, China, 518055.
Abstract:
The total synthesis of endolides A and B has been achieved in a concise, highly stereoselective fashion (12 steps, 16.2% and 16.0% overall yields, respectively). Key features of the route include a modified Negishi coupling between 3-bromofuran and an organozinc reagent derived from an iodoalanine derivative for the synthesis of 3-(3-furyl)-alanine derivative, and a judicious choice of reaction conditions to surmount the conformational constraints placed by converting a linear peptide into the corresponding macrocycle.
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