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Intestinal Microbiota in Common Chronic Inflammatory Disorders Affecting Children
Anna Torun1, Anna Hupalowska2, Piotr Trzonkowski3
1Chair and Department of Biochemistry, Medical University of Warsaw, Warsaw, Poland.
Frontiers in Immunology
|June 24, 2021
Summary
Pediatric chronic inflammatory disorders are linked to gut microbiome changes. New immunotherapies, enhanced by gut microbiota modulation, show promise for treating conditions like inflammatory bowel disease and autoimmune diseases.
Area of Science:
- Pediatric immunology and gastroenterology.
- Microbiome research and immune system interactions.
Background:
- Rising incidence of pediatric chronic inflammatory disorders.
- Gut microbiome alterations implicated in inflammatory bowel disease (IBD), type 1 diabetes mellitus (T1DM), and celiac disease (CeD).
- Current therapies offer symptomatic relief but lack sustained improvements.
Purpose of the Study:
- Review pathogenic mechanisms of pediatric chronic inflammatory disorders.
- Summarize the role of gut microbiota disturbances.
- Explore novel therapeutic strategies targeting the microbiome and immune system.
Main Methods:
- Review of recent preclinical studies and clinical trials.
- Analysis of pathogenic mechanisms and microbiota composition.
- Evaluation of immunotherapies and microbiota modulation.
Main Results:
- Gut microbiota composition and abundance are key factors in IBD, T1DM, and CeD development.
- New approaches like engineered T cells show therapeutic potential.
- Microbiota manipulation can enhance immunotherapy responses.
Conclusions:
- Targeting the gut microbiome and immune system offers promising avenues for pediatric chronic inflammatory disorders.
- Restoring gut microbiota balance is crucial for long-term health benefits.
- Integrated therapeutic strategies hold potential for improved quality of life in affected children.
Keywords:
adoptive cell therapychronic inflammatory disordersimmune homeostasismicrobiotapediatric diseasesregulatory T cellsMore Related Videos
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