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Updated: Nov 1, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Metal-ligand-Lewis acid multi-cooperative catalysis: a step forward in the Conia-ene reaction
Arnaud Clerc1, Enrico Marelli1, Nicolas Adet1
1Laboratoire Hétérochimie Fondamentale et Appliquée (UMR 5069), Université de Toulouse (UPS), CNRS 118 route de Narbonne F-31062 Toulouse France dbouriss@chimie.ups-tlse.fr bmv@chimie.ups-tlse.fr.
Abstract:
An original multi-cooperative catalytic approach was developed by combining metal-ligand cooperation and Lewis acid activation. The [(SCS)Pd]2 complex featuring a non-innocent indenediide-based ligand was found to be a very efficient and versatile catalyst for the Conia-ene reaction, when associated with Mg(OTf)2. The reaction operates at low catalytic loadings under mild conditions with HFIP as a co-solvent. It works with a variety of substrates, including those bearing internal alkynes. It displays complete 5-exo vs. 6-endo regio-selectivity. In addition, except for the highly congested Bu-substituent, the reaction occurs with high Z vs. E stereo-selectivity, making it synthetically useful and complementary to known catalysts.
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