Carbon monoxide and hydrogen (syngas) as a C1-building block for selective catalytic methylation
Akash Kaithal1,2, Markus Hölscher2, Walter Leitner1,2
1Max Planck Institute for Chemical Energy Conversion Stiftstraße 34-36 Mülheim a.d. Ruhr 45470 Germany walter.leitner@cec.mpg.de.
Abstract:
A catalytic reaction using syngas (CO/H2) as feedstock for the selective β-methylation of alcohols was developed whereby carbon monoxide acts as a C1 source and hydrogen gas as a reducing agent. The overall transformation occurs through an intricate network of metal-catalyzed and base-mediated reactions. The molecular complex [Mn(CO)2Br[HN(C2H4P Pr2)2]] 1 comprising earth-abundant manganese acts as the metal component in the catalytic system enabling the generation of formaldehyde from syngas in a synthetically useful reaction. This new syngas conversion opens pathways to install methyl branches at sp3 carbon centers utilizing renewable feedstocks and energy for the synthesis of biologically active compounds, fine chemicals, and advanced biofuels.
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