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Simultaneous determination of carbamazepine and its epoxide and transdiol metabolites in plasma by microbore liquid
1Dept. of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis 55455.
Abstract:
Simultaneous monitoring of carbamazepine and its metabolities is helpful in providing information on the induction process via the epoxide-diol route. The present method involves the liquid-chromatographic analysis of 1.0 mL of plasma for carbamazepine at concentrations of 0.025 to 4.0 mg/L and for both the 10,11-epoxide and 10,11-transdiol metabolites at concentrations of 0.01 to 1.0 mg/L. Weighted regression equations, expressing peak area ratios as a function of concentrations of carbamazepine and its epoxide and transdiol metabolites in the standards, were used to determine concentrations in plasma samples.
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