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SGLT-2i and Risk of Malignancy in Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials

Nanjing Shi1, Yetan Shi2, Jingsi Xu2

  • 1Department of Endocrinology, Affiliated Hangzhou First People' Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Frontiers in Public Health
|June 24, 2021
PubMed

Insights

This meta-analysis found that sodium-glucose cotransporter 2 inhibitors (SGLT-2i) generally do not increase overall malignancy risk in type 2 diabetes patients. However, specific SGLT-2i drugs like ertugliflozin and dapagliflozin may elevate risk, while empagliflozin shows mixed results.

Area of Science:

  • Endocrinology
  • Oncology
  • Pharmacology

Background:

  • The association between sodium-glucose cotransporter 2 inhibitors (SGLT-2i) and cancer risk requires further clarification.
  • Type 2 diabetes (T2D) patients are a key population for evaluating these risks due to their metabolic profile.

Conclusions:

  • Ertugliflozin and dapagliflozin may increase malignancy risk in T2D patients.
  • Empagliflozin's effect on malignancy risk is complex, potentially decreasing it compared to active agents but increasing it versus placebo, especially for digestive system cancers.
  • The precise relationship between SGLT-2 inhibitors and malignancy risk in T2D patients remains uncertain and warrants further investigation.
Keywords:
RCTSGLT-2imalignant tumormeta-analysistype 2 diabetes

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