Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

13.5K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
13.5K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

6.3K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
6.3K
Inflammatory Response01:28

Inflammatory Response

13.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
13.8K
Inflammation01:38

Inflammation

56.9K
Overview
56.9K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

498
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
498
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

465
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
465

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developmental genetic determinants of the human cerebrospinal fluid-ventricular system.

Science translational medicine·2026
Same author

Quality of life: a neglected aspect in male infertility studies.

International braz j urol : official journal of the Brazilian Society of Urology·2026
Same author

Advancements in RNA-based therapies from bench to bedside.

npj drug discovery·2026
Same author

Integrating transcriptomics and gene-level interpretable probabilistic Tsetlin Machine reveals elevated pancreatic cancer risk in Type 2 diabetes.

Computational biology and chemistry·2026
Same author

Using Computational Intelligence to Connect Data and Drug Design in Medicinal Chemistry: A Review.

Current drug discovery technologies·2026
Same author

Pathway and efflux engineering to utilize endogenous high isoprenoid flux in <i>Azospirillum brasilense</i> Sp7 for sesquiterpene production.

Applied and environmental microbiology·2026

Related Experiment Video

Updated: Nov 1, 2025

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
06:50

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

2.0K

Inflammatory hydrocephalus.

Stephanie M Robert1, Benjamin C Reeves1, Arnaud Marlier1

  • 1Department of Neurosurgery, Yale School of Medicine, New Haven, CT, 06510, USA.

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery
|June 24, 2021
PubMed
Summary
This summary is machine-generated.

Inflammation can cause hydrocephalus, including post-hemorrhagic (PHH) and post-infectious (PIH) types. Rethinking these as "inflammatory hydrocephalus" may reveal new immunomodulatory treatments.

Keywords:
CSF hypersecretionChoroid plexus epitheliumInflammationPost-hemorrhagic hydrocephalusPost-infectious hydrocephalus

More Related Videos

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

15.1K
Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model
08:18

Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model

Published on: February 8, 2022

2.6K

Related Experiment Videos

Last Updated: Nov 1, 2025

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
06:50

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

2.0K
Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

15.1K
Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model
08:18

Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model

Published on: February 8, 2022

2.6K

Area of Science:

  • Neuroscience
  • Immunology
  • Pathology

Background:

  • Reparative inflammation is crucial for defense but can cause disease if dysregulated.
  • Post-hemorrhagic hydrocephalus (PHH) and post-infectious hydrocephalus (PIH) are common, often requiring invasive cerebrospinal fluid (CSF) diversion.
  • Current treatments for PHH and PIH have high complication and failure rates.

Purpose of the Study:

  • To discuss the concept of "inflammatory hydrocephalus" by highlighting shared mechanisms between PHH and PIH.
  • To explore potential therapeutic vulnerabilities in these conditions.
  • To propose a shift in perspective from lifelong neurosurgical management to potentially preventable immunomodulatory treatments.

Main Methods:

  • Review of clinical studies in human patients.
  • Analysis of cerebrospinal fluid (CSF) cytokine and immune cell profiles in PHH and PIH.
  • Integration of recent findings from model systems.

Main Results:

  • PHH and PIH, despite different causes, exhibit similar CSF cytokine and immune cell profiles.
  • Shared inflammatory mechanisms may underlie both conditions.
  • These shared pathways suggest potential targets for immunomodulation.

Conclusions:

  • The concept of "inflammatory hydrocephalus" unifies understanding of PHH and PIH.
  • Immunomodulation offers a promising alternative or adjunct to current neurosurgical treatments.
  • Viewing PHH and PIH as inflammatory conditions could lead to preventative strategies.