Visible-Light-Driven Redox Neutral Direct C-H Amination of Glycine Derivatives and Peptides with
Xiaoyun Zhao1, Bai Li1, Jingyao Xu1
1School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, P. R. China.
Abstract:
A room temperature, visible-light-promoted and redox neutral direct C-H amination of glycine and peptides has been firstly accomplished by using N-acyloxyphthalimide or -succinimide as nitrogen-radical precursor. The present strategy provides ways to introduce functionalities such as N-acyloxyphthalimide or -succinimide specifically to terminal glycine segment of peptides. Herein, mild conditions and high functional-group tolerance allow the preparation of non-natural α-amino acids and modification of corresponding peptides in this way.
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