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Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

Asthma-IV: Nursing Management

Asthma-IV: Nursing Management

The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Contemporary Concise Review 2020: Asthma.

Gang Wang^1,2, Vanessa M McDonald³

¹Department of Respiratory and Critical Care Medicine, Clinical Research Centre for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, China.

Respirology (Carlton, Vic.)

|June 24, 2021

Summary

This summary is machine-generated.

Asthma patients faced increased burdens during the 2020 bushfires. However, controlled asthma did not increase severe COVID-19 risk, highlighting personalized medicine and microbiome research for future asthma management.

Keywords:

asthma epithelial microbiota personalized medicine treatable traits

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Area of Science:

Environmental Health
Infectious Diseases
Pulmonology

Background:

The 2019/2020 bushfire season significantly impacted asthma patients, increasing their burden compared to the general population.
Controlled asthma patients did not exhibit higher risks for severe coronavirus disease 2019 (COVID-19) infection or mortality.
Oral corticosteroid (OCS) use in asthma management presents a substantial burden, necessitating OCS stewardship.

Purpose of the Study:

To review the impact of environmental factors and infectious diseases on asthma.
To explore the role of personalized medicine, including treatable traits and patient engagement, in modern asthma management.
To discuss advancements in severe asthma treatment, such as biologic therapies and biomarker-guided treatment selection.

Main Methods:

Literature review and synthesis of current research on asthma, bushfires, COVID-19, personalized medicine, and microbiome.
Analysis of the impact of environmental exposures on asthma exacerbations and control.
Examination of the role of epithelial barriers, airway immunity, and microbial dysregulation in asthma pathogenesis.

Main Results:

Asthma patients experienced a heightened burden during the 2019/2020 bushfire season.
Controlled asthma is not associated with increased severe COVID-19 risk.
Biologic therapies show promise in reducing severe asthma exacerbations, with biomarkers aiding treatment selection.

Conclusions:

Personalized medicine, utilizing treatable traits, represents the future of asthma management.
Further research into patient engagement in personalized medicine strategies is crucial.
Understanding the role of the lung, gut, and skin microbiome in asthma pathogenesis requires further investigation.