Association Between White Blood Cell Counts and Brachial-Ankle Pulse Wave Velocity in Chinese Hypertensive Adults: A

Buyun Jia1, Chongfei Jiang2, Yun Song2

  • 1College of Integrative Medicine, Anhui University of Chinese Medicine, Hefei, People's Republic of China.

Angiology
|June 24, 2021
PubMed

Insights

Higher white blood cell (WBC) counts are linked to increased arterial stiffness in adults with hypertension. This finding suggests a connection between WBC levels and cardiovascular risk factors like brachial-ankle pulse wave velocity (baPWV).

Area of Science:

  • Cardiology
  • Hematology
  • Hypertension Research

Background:

  • Increased arterial stiffness is common in hypertensive patients, elevating cardiovascular risk.
  • Elevated white blood cell (WBC) counts may independently contribute to arterial stiffness and cardiovascular events.

Purpose of the Study:

  • To examine the association between differential white blood cell (WBC) counts and brachial-ankle pulse wave velocity (baPWV) in adults with hypertension.

Main Methods:

  • Utilized a multivariate linear regression model for correlation analysis.
  • Included 14,390 participants in the final analysis.
  • Assessed WBC counts as continuous variables, categories, and quartiles.

Main Results:

  • Higher WBC counts showed a significant positive association with greater baPWV (adjusted β = 10; 95% CI, 8-13; P < .001).
  • This association remained significant when WBC counts were analyzed in categories or quartiles.
  • Differential WBC subtypes, including neutrophils and lymphocytes, also demonstrated similar positive associations with baPWV.

Conclusions:

  • Brachial-ankle pulse wave velocity (baPWV) is positively associated with differential white blood cell (WBC) counts in hypertensive adults.
  • Elevated WBC counts may serve as a potential biomarker for arterial stiffness in this population.
  • Further research could explore the clinical implications of these findings for cardiovascular risk stratification in hypertension.

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