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Updated: Nov 1, 2025

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
Published on: December 1, 2023
Autoimmune glomerulonephritis in a multiple sclerosis patient after cladribine treatment
Kristina Schönfelder1, Helene Schuh2, Frederick Pfister3
1Department of Nephrology, University Medicine Essen, Essen, Germany Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, Essen, Germany.
Background:
Oral cladribine is an approved disease-modifying drug for the treatment of relapsing multiple sclerosis. In controlled clinical trials as well as in post marketing safety assessments, autoimmune conditions have not yet been reported as a specific side effect of cladribine.
Objective And Results:
Here, we report a case of anti-glomerular basement membrane antibody-mediated glomerulonephritis that occurred shortly after the fourth cladribine treatment cycle.
Conclusion:
Neurologists should be attentive to the development of secondary autoimmunity in cladribine-treated patients.
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