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Creatinine clearance evaluation in routine diabetes practice.

P J Guillausseau1, A Fontbonne, J Cahen-Varsaux

  • 1Department of Endocrinology and Diabetes, Hôpital Lariboisière, Paris, France.

Diabetes Research (Edinburgh, Scotland)
|March 1, 1988
PubMed
Summary
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Creatinine clearance estimation methods are reliable for diabetic patients in clinical practice. These methods show good correlation with direct measurements and offer better day-to-day consistency.

Area of Science:

  • Nephrology
  • Endocrinology
  • Clinical Chemistry

Background:

  • Creatinine clearance (CrCl) measurement via timed urine collection lacks reliability in routine practice.
  • Established CrCl estimation methods exist but require validation in diabetic populations.

Purpose of the Study:

  • To assess the validity of established creatinine clearance estimation methods in diabetic patients.
  • To compare the reliability of estimated versus measured CrCl in this cohort.

Main Methods:

  • CrCl was determined in 33 diabetic patients over two consecutive days.
  • Methods included direct measurement and estimations using Kampmann et al., Bjornsson et al., and Cockcroft and Gault formulas.
  • Correlation and day-to-day variation were analyzed.

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Main Results:

  • A strong correlation (r = 0.73-0.75, p < 0.001) was found between measured and estimated CrCl.
  • Correlation was stronger in men than in women.
  • Day-to-day variation was significantly lower for estimated CrCl (approx. 17%) compared to direct measurement (28%).

Conclusions:

  • Creatinine clearance estimation methods are suitable for routine clinical practice in diabetic patients.
  • Estimated CrCl offers improved day-to-day reliability over direct measurement in this population.