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Eosinophils and helminth infection: protective or pathogenic?
1Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Seminars in Immunopathology
|June 24, 2021
Summary
Eosinophils play a dual role in helminth infections, contributing to both protection and disease. Their exact function in immunity, pathogenesis, and regulation during these infections requires further investigation.
Area of Science:
- Immunology
- Parasitology
- Infectious Diseases
Background:
- Eosinophils are key immune cells involved in helminth infections.
- Their precise role in host defense and disease pathogenesis is not fully understood.
- Factors like parasite diversity and immune system complexity contribute to this knowledge gap.
Purpose of the Study:
- To review the multifaceted roles of eosinophils in helminth infections.
- To explore eosinophils' impact on protective immunity.
- To examine their contribution to pathogenesis and immunoregulation.
Main Methods:
- Literature review of in vitro studies, human infections, and animal models.
- Analysis of existing data on eosinophil functions in helminthic contexts.
- Synthesis of information on immune responses and parasite heterogeneity.
Main Results:
- Eosinophils exhibit both beneficial and detrimental effects during helminth infections.
- Their functions are diverse and context-dependent.
- Understanding eosinophil roles is crucial for developing effective treatments.
Conclusions:
- Eosinophils are critical players in helminth infection immunity.
- Further research is needed to elucidate their complex functions.
- Targeting eosinophils may offer therapeutic strategies for helminthic diseases.
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