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TRP channels in COVID-19 disease: Potential targets for prevention and treatment

Sahar M Jaffal1, Manal A Abbas2

  • 1Department of Biological Sciences, Faculty of Science, The University of Jordan, 11942, Amman, Jordan.

Chemico-Biological Interactions
|June 24, 2021
PubMed

Insights

Transient Receptor Potential (TRP) channels may play a role in COVID-19 symptoms and complications. Targeting these TRP channels offers potential avenues for preventing and treating SARS-CoV-2 infections.

Area of Science:

  • Physiology
  • Molecular Biology
  • Virology

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, presents with diverse symptoms including respiratory and gastrointestinal issues.
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes ACE2 and TMPRSS2 proteins for cellular entry.
  • Transient Receptor Potential (TRP) channels are expressed in various tissues and are implicated in physiological processes.

Purpose of the Study:

  • To review the potential role of TRP channels in the pathophysiology of COVID-19.
  • To explore TRP channels as therapeutic targets for COVID-19 treatment and prevention.

Main Methods:

  • Literature review of studies investigating TRP channels and SARS-CoV-2.
  • Analysis of TRP channel involvement in COVID-19 symptoms and mechanisms.

Main Results:

  • TRP channels are expressed in tissues targeted by SARS-CoV-2.
  • TRP channels may contribute to inflammation, pain, fever, and various organ complications associated with COVID-19.
  • Active compounds targeting TRP channels have shown efficacy against SARS-CoV-2.

Conclusions:

  • TRP channels are implicated in multiple facets of COVID-19, from viral entry to symptom manifestation.
  • Modulating TRP channel activity through antibodies, aptamers, small molecules, or venoms presents a promising strategy for COVID-19 management.
  • Further research is needed to elucidate specific TRP channel roles and optimize therapeutic interventions.
Keywords:
COVID-19PreventionSARS-CoV-2SymptomsTRP channelsTreatment

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