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Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
Cancer cell membrane camouflaged iridium complexes functionalized black-titanium nanoparticles for
Jinchao Shen1, Johannes Karges2, Kai Xiong1
1MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510006, PR China.
Abstract:
The diagnosis and treatment of cancer is one of the biggest medical challenges of the century. Despite significant improvements, there remains an urgent need for novel anticancer procedures. Among the most promising approaches, increasing attention has been devoted towards photothermal and sonodynamic therapy in which sensitizers are activated upon light/ultrasound radiation to generate a cytotoxic effect. While these methods have undoubtedly shown a high therapeutic success, these techniques are intrinsically limited. Herein, the functionalization of black-titanium nanoparticle with iridium complexes and cancer cell membranes in a nanoplatform for hierarchical targeted synergistic photothermal and sonodynamic cancer imaging and therapy is proposed. The particles showed to generate efficiently heat upon irradiation and catalytically form reactive oxygen species upon ultrasound radiation. The nanoparticle formulation demonstrated to selectively localize in the mitochondria as well as to preferentially accumulate in cancerous over non-cancerous cells as well as in the tumor inside a mouse model, presenting a hierarchical targeting strategy. Upon synergistic irradiation at 1064 nm and ultrasound radiation, the nanoparticles were able to act as an imaging agent and identify the tumor site with high spatial resolution as well as act as a therapeutic agent and completely eradicate a tumor inside a mouse model.
Insights
This study introduces a novel nanoplatform combining photothermal and sonodynamic cancer therapy. The functionalized nanoparticles effectively target cancer cells, image tumors, and eradicate them upon dual irradiation.
Area of Science:
- Nanotechnology
- Biomedical Engineering
- Oncology
Background:
- Cancer diagnosis and treatment remain significant global health challenges.
- Photothermal therapy (PTT) and sonodynamic therapy (SDT) show promise but have limitations.
- Novel strategies are needed for enhanced cancer imaging and therapy.
Purpose of the Study:
- To develop a nanoplatform for hierarchical targeted synergistic photothermal and sonodynamic cancer imaging and therapy.
- To functionalize black-titanium nanoparticles with iridium complexes and cancer cell membranes.
Main Methods:
- Fabrication of a nanoplatform using black-titanium nanoparticles, iridium complexes, and cancer cell membranes.
- Evaluation of photothermal and sonodynamic properties upon irradiation.
- Assessment of targeted accumulation in cancer cells and tumors in a mouse model.
- In vivo imaging and therapeutic efficacy testing using synergistic irradiation.
Main Results:
- Nanoparticles efficiently generated heat under irradiation and reactive oxygen species under ultrasound.
- Demonstrated hierarchical targeting: selective mitochondrial localization and preferential accumulation in cancer cells and tumors.
- Successfully imaged tumors with high spatial resolution and completely eradicated tumors in a mouse model.
Conclusions:
- The developed nanoplatform offers a promising strategy for synergistic cancer therapy and imaging.
- Hierarchical targeting enhances therapeutic efficiency and reduces off-target effects.
- This approach holds potential for improved clinical outcomes in cancer treatment.
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