[Postoperative radiation of retinoblastoma--report on 22 patients]

From July 1958 to December 1979, 22 patients with retinoblastoma were treated postoperatively by radiotherapy. All were proved by pathology. There were 12 stage I, 1 stage II, 8 stage III and 1 stage IV lesions. Radiation dose was more than 15 Gy and most of the patients received 40-50 Gy in 4-5 weeks. The overall cancer free 5 year survival rate was 55% (12/22). The 5 year survival rate of stage I patients was 75% (9/12), and that of stage III patients was 38% (3/8). None of the stage II and IV patients survived. Dose of 40-50 Gy/4-5 wk is considered to be optimal for control of the tumor. Dose higher than 60 Gy/6 wk could lead to retarded growth in the orbital and temporal bony structures if the patient survives for ten years or more.