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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
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Pediatric acute respiratory distress syndrome: How to protect the lungs during mechanical ventilation?

Álvaro Coronado-Muñoz1,2, Raffo Escalante-Kanashiro3,4

  • 1Department of Pediatrics, University of Texas Health Science Center, Houston, Texas, USA.

Boletin Medico Del Hospital Infantil De Mexico
|June 24, 2021
PubMed

Insights

Pediatric acute respiratory distress syndrome (PARDS) is a common critical care diagnosis. Management evolves with new definitions and evidence, focusing on lung protection strategies during mechanical ventilation to reduce mortality.

Area of Science:

  • Critical care medicine
  • Pediatric pulmonology
  • Respiratory medicine

Background:

  • Pediatric acute respiratory distress syndrome (PARDS) is a frequent critical care diagnosis.
  • PARDS involves stages of hypoxia requiring severity-dependent management.
  • Recent epidemiological data refine understanding of PARDS mortality and ventilation impacts.

Purpose of the Study:

  • To provide a comprehensive narrative review of Pediatric Acute Respiratory Distress Syndrome (PARDS).
  • To prioritize critical management strategies for pediatric patients with PARDS.
  • To discuss evolving definitions and their impact on understanding PARDS.

Main Methods:

  • Narrative review of existing literature on PARDS.
  • Analysis of updated definitions and epidemiological evidence.
  • Discussion of mechanical ventilation strategies and alternative therapies.

Main Results:

  • Lung protective ventilation strategies have successfully reduced PARDS mortality and complications.
  • Newer definitions aid in understanding PARDS epidemiology and outcomes.
  • Alternative therapies may be considered when high-level support is limited.

Conclusions:

  • Effective management of PARDS relies on updated definitions and evidence-based strategies.
  • Lung protection during mechanical ventilation is crucial for improving outcomes.
  • Careful consideration of alternative therapies can support critically ill pediatric patients.

Keywords:
Acute lung injuryAdultAdultoArtificial respiration/methodsLesión pulmonar agudaPediatricsPediatríaPosición pronoProne positionRespiración artificial, métodosRespiratory distress syndromeSíndrome de dificultad respiratoria aguda

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