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Related Concept Videos

Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
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Immune Surveillance by NK Cells and Phagocytes01:25

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Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
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Related Experiment Video

Updated: Nov 1, 2025

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
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Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

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Recent Advances in Human Natural Killer Cells.

L Moretta, E Ciccone, R Biassoni

    International Archives of Allergy and Immunology
    |June 25, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Human Natural Killer (NK) cells can recognize specific foreign cells, with their function linked to HLA class I molecules and a newly identified 58 kD surface receptor. This discovery reshapes understanding of NK cell alloantigen recognition.

    Keywords:
    HLA class I and NK recognitionHLA-CNK cell clonesNK cell developmentNK cell precursorsNK cell receptorsNK cell repertoireNK cell-mediated allospecificity

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    Expansion, Purification, and Functional Assessment of Human Peripheral Blood NK Cells
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    Expansion, Purification, and Functional Assessment of Human Peripheral Blood NK Cells

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    Expansion, Purification, and Functional Assessment of Human Peripheral Blood NK Cells
    10:44

    Expansion, Purification, and Functional Assessment of Human Peripheral Blood NK Cells

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    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Human Natural Killer (NK) cells have undergone significant re-evaluation regarding their functions and development.
    • NK cell precursors capable of differentiating into NK cells have been identified within the human thymus.

    Purpose of the Study:

    • To review recent advancements in understanding human NK cell ontogeny and function.
    • To explore the mechanisms of specific alloantigen recognition by NK cells and identify associated surface molecules.

    Main Methods:

    • Analysis of immature thymocyte populations for NK cell differentiation potential.
    • Isolation and characterization of NK cell clones with defined allospecificities.
    • Identification of surface molecules on NK cells using monoclonal antibodies.

    Main Results:

    • NK cells demonstrate a clonally distributed ability to specifically recognize allogeneic cells.
    • Human Leukocyte Antigen (HLA) class I molecules, such as HLA-Cw3, play a role in protecting target cells from NK cell-mediated lysis.
    • A novel family of 58 kD surface molecules on NK cells correlates with specific allospecificity recognition.

    Conclusions:

    • Human NK cells possess a repertoire for recognizing alloantigens, challenging previous concepts.
    • HLA class I molecules are central to NK cell functions.
    • The 58 kD molecules are likely components of the receptors mediating NK cell alloantigen recognition.