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Related Concept Videos

Cross-reactivity00:42

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
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Related Experiment Video

Updated: Nov 1, 2025

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
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Clinically Significant Cross-Reactivities among Allergens.

Rob C Aalberse

    International Archives of Allergy and Immunology
    |June 25, 2021
    PubMed
    Summary

    Unexpected crossreactivity of Immunoglobulin E (IgE) antibodies can be confusing. Even without symptoms, crossreactivity may prime immune responses to new allergens, impacting allergy testing interpretation.

    Area of Science:

    • Immunology
    • Allergy Diagnostics

    Background:

    • Immunoglobulin E (IgE) antibody crossreactivity can present unexpected and confusing clinical implications.
    • The clinical significance of serologic crossreactivities varies; some elicit symptoms, while others do not.
    • Asymptomatic crossreactivity may play a role in inducing immune responses to novel antigens, termed 'crossreactive priming'.

    Purpose of the Study:

    • To clarify the implications of IgE antibody crossreactivity in allergy diagnostics.
    • To highlight the relevance of crossreactivity, even in the absence of immediate clinical symptoms.
    • To emphasize the importance of understanding crossreactivity for accurate interpretation of IgE antibody assay results.

    Main Methods:

    • Review of existing literature on IgE antibody crossreactivity.
    Keywords:
    AllergensCross-reactivityFood allergyIgE antibodiesRAST

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  • Analysis of serologic data and clinical outcomes related to crossreactive allergens.
  • Discussion of the immunological mechanisms underlying crossreactive priming.

    • Main Results:

    • IgE crossreactivity can be clinically significant even when not producing immediate symptoms.
    • Crossreactive priming, induced by asymptomatic crossreactivity, can influence future immune responses.
    • Detection of IgE antibodies to an allergen does not confirm prior exposure to that specific allergen.

    Conclusions:

    • Accurate interpretation of IgE antibody assays requires consideration of crossreactivity.
    • Understanding crossreactivity is crucial for diagnosing and managing allergic conditions.
    • The concept of crossreactive priming broadens the understanding of IgE-mediated immune responses.