Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

29.4K
Overview
29.4K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

2.8K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.8K
Hypersensitivities01:30

Hypersensitivities

3.1K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
3.1K
Cross-reactivity00:42

Cross-reactivity

31.9K
Overview
31.9K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.1K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.1K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

1.4K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nonsteroidal anti-inflammatory drug hypersensitivity syndrome: a multicenter study. II. Basophil activation by nonsteroidal anti-inflammatory drugs and its impact on pathogenesis.

Journal of investigational allergology & clinical immunology·2010
Same author

Nonsteroidal anti-inflammatory drug hypersensitivity syndrome. A multicenter study. I. Clinical findings and in vitro diagnosis.

Journal of investigational allergology & clinical immunology·2009
Same author

Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GALEN platform. The Galenda project.

Allergy·2009
Same author

Cellular tests in the diagnosis of drug hypersensitivity.

Current pharmaceutical design·2008
Same author

Diagnostic tests based on human basophils: more potentials and perspectives than pitfalls.

International archives of allergy and immunology·2008
Same author

Hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs).

Current pharmaceutical design·2006

Related Experiment Video

Updated: Nov 1, 2025

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

10.2K

Perspectives in Allergy Diagnosis.

A L de Weck

    International Archives of Allergy and Immunology
    |June 25, 2021
    PubMed
    Summary

    Advancements in allergy diagnostics include telethermography for reaction evaluation and new cellular tests. These methods offer improved quantitative insights and aid in diagnosing allergic and pseudo-allergic conditions.

    Area of Science:

    • Immunology
    • Allergy Diagnostics
    • Medical Technology

    Background:

    • Current allergy diagnostic methods, including serological tests for allergen-specific immunoglobulin E (IgE), have limitations.
    • Quantitative evaluation of immediate and late-phase allergic reactions requires further refinement.

    Purpose of the Study:

    • To explore recent advancements in allergy diagnosis.
    • To evaluate the utility of telethermography and novel cellular assays in allergy diagnostics.

    Main Methods:

    • Telethermography for quantitative evaluation of immediate and late-phase allergic reactions.
    • Comparative studies of serological tests for allergen-specific IgE.
    • Development and application of cellular tests, specifically measuring sulfidoleukotrienes from cytokine-primed basophils.
    Keywords:
    HistamineIgE serologyLate phase reactionSkin testsSulfido leukotrienesThermography

    More Related Videos

    Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
    07:10

    Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

    Published on: April 21, 2019

    16.6K
    Basophil Activation Test for Allergy Diagnosis
    07:22

    Basophil Activation Test for Allergy Diagnosis

    Published on: May 31, 2021

    8.7K

    Related Experiment Videos

    Last Updated: Nov 1, 2025

    A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
    06:34

    A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

    Published on: June 4, 2017

    10.2K
    Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
    07:10

    Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

    Published on: April 21, 2019

    16.6K
    Basophil Activation Test for Allergy Diagnosis
    07:22

    Basophil Activation Test for Allergy Diagnosis

    Published on: May 31, 2021

    8.7K

    Main Results:

    • Telethermography provides enhanced quantitative evaluation of allergic reactions, beneficial for pharmacological studies.
    • Serological IgE tests are helpful but not definitive diagnostic tools.
    • Cellular assays measuring sulfidoleukotrienes show promise for diagnosing allergic and pseudo-allergic diseases.

    Conclusions:

    • Telethermography offers improved quantitative assessment of allergic reactions.
    • Novel cellular tests, like sulfidoleukotriene determination, represent a promising new avenue for allergy and pseudo-allergy diagnosis.