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Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
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V-Alpha-14 T-Cell Antigen Receptor Repertoire and Its Function

Haruhiko Koseki, Yasuhiko Makino, Yoshihiro Adachi

    International Archives of Allergy and Immunology
    |June 25, 2021
    PubMed

    A homogenous TCR repertoire Vα14Jα281 with a one-base N region which is dominated at a high frequency (2-4%) in periphery, was characterized by PCR and RNase protection assays. Surprisingly, Vα14 T cells develop in extrathymic tissues. In addition, although Vα14 T cells recognize a self-component on hematopoietic cells, they are not eliminated and proliferate in periphery, indicating that Vα14 T cells are distinct subsets from the thymic repertoire. Moreover, Vα14Jα281 TCR expression is dramatically reduced when non-obese diabetic, BWF1 and C3H Ipr mice develop autoimmune diseases. It could be hypothesized that the Vα14 T cells play a special role in the regulation of immune responses.

    Keywords:
    Autoimmune diseaseAutoreactiveExtrathymic T cell developmentImmuneregulationTCR

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