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Adenomyosis - its possible effect on endometrial function and receptivity
Adenomyosis impacts endometrial function and receptivity, potentially causing infertility. Understanding its pathogenesis and improving diagnostics are key for effective treatment and enhanced quality of life.
Area of Science:
- Reproductive medicine
- Gynecology
Background:
- Adenomyosis significantly impairs women's quality of life.
- Pathogenesis, diagnostics, and treatment of adenomyosis remain subjects of ongoing research and varied opinions.
Purpose of the Study:
- To present current knowledge on adenomyosis.
- To elucidate the impact of adenomyosis on endometrial function and receptivity.
Main Methods:
- Comprehensive literature search of PubMed/Medline, Web of Sciences, and Scopus databases.
- Inclusion of English-indexed articles until February 2021.
- Keywords: adenomyosis, endometrial receptivity, infertility.
Main Results:
- Recent research highlights angiogenesis and epithelial-mesenchymal transition in adenomyosis pathogenesis.
- Diagnostic methods include transvaginal ultrasound, MRI, hysteroscopy, with histopathology for confirmation.
- Classification should follow #Enzian guidelines; treatment requires individualized approach and specialized centers.
Conclusions:
- Adenomyosis disrupts endometrial vascularization and epithelial-mesenchymal transition, leading to irregular bleeding and implantation failure.
- Endometrial proteome analysis may reveal novel therapeutic targets for adenomyosis.
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