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Related Concept Videos

Genetic Screens02:46

Genetic Screens

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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CRISPR01:59

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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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Pooled CRISPR-Based Genetic Screens in Mammalian Cells
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VISPR-online: a web-based interactive tool to visualize CRISPR screening experiments.

Yingbo Cui1, Zihang Wang2, Johannes Köster3

  • 1School of Computer, National University of Defense Technology, Changsha, 410073, China. yingbocui@nudt.edu.cn.

BMC Bioinformatics
|June 25, 2021
PubMed
Summary
This summary is machine-generated.

VISPR-online is a new web-based tool for visualizing and analyzing CRISPR screening data. It supports multiple analysis tools and facilitates easy data sharing among researchers.

Keywords:
CRISPRCRISPR screeningVISPRVisualization

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Area of Science:

  • CRISPR screening
  • Bioinformatics
  • Data visualization

Background:

  • VISPR is a desktop tool for CRISPR screening analysis but has limitations.
  • It only supports MAGeCK output and requires manual setup.
  • VISPR is not designed for collaborative data sharing.

Purpose of the Study:

  • To develop an accessible, web-based platform for CRISPR screening data analysis.
  • To enhance data visualization, exploration, and sharing capabilities for researchers.
  • To broaden compatibility with different CRISPR analysis tools.

Main Methods:

  • Developed VISPR-online, a user-friendly web application.
  • Integrated support for MAGeCK, BAGEL, and JACKS analysis outputs.
  • Implemented features for interactive exploration and data sharing.

Main Results:

  • VISPR-online enables easy online visualization and exploration of CRISPR screening results.
  • Users can visualize read count changes and gene essentiality.
  • The platform allows users to share and resume their screening data analysis.

Conclusions:

  • VISPR-online provides a versatile, accessible platform for CRISPR screening data.
  • It supports multiple analysis tools and facilitates collaboration.
  • The tool is freely available online with source code provided.