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Lipid Bilayer Vesicle Generation Using Microfluidic Jetting

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting

Published on: February 21, 2014

A liquid breakdown driven non-invasive microjet injection system.

Hwichan Ham¹, Jack J Yoh¹

¹Department of Aerospace Engineering, Seoul National University, 1 Gwanakro, Gwanakgu, Seoul, 08826, Republic of Korea.

Medical Engineering & Physics

|June 25, 2021

Summary

This summary is machine-generated.

Researchers developed a microjet injector for less painful drug delivery. This device uses electrical or optical energy for precise, skin-penetrating injections, showing promise for medical applications.

Keywords:

Dielectric breakdown Intradermal drug delivery Laser-induced breakdown Microjet Needle-free

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Area of Science:

Biomedical Engineering
Drug Delivery Systems
Medical Device Development

Background:

Minimally invasive drug delivery is crucial for reducing pain and tissue damage.
Existing injection methods can cause discomfort and variable drug absorption.
Advanced technologies are needed for precise, controlled intradermal drug administration.

Purpose of the Study:

To develop a microjet injector with skin-penetratable jet speed, small volume, and high repeatability.
To evaluate the medical efficacy of the microjet for reduced tissue destruction and pain.
To compare the performance of dielectric and laser-induced liquid breakdown for microjet generation.

Main Methods:

Development of a microjet injector utilizing electrical and optical energy sources.
Conversion of energy into kinetic energy of the drug solution via liquid breakdown (dielectric or laser-induced).
Evaluation of medical efficacy through ex-vivo and in-vivo mouse models.

Main Results:

Both dielectric and laser-induced breakdown generated skin-penetrable jet speeds of 200-330 m/s.
Dielectric breakdown showed increased driving pressure with energy, suitable for deep penetration.
Laser-induced breakdown exhibited energy conversion efficiency limitations.
Microjet injections demonstrated efficacy in mouse models.

Conclusions:

The developed microjet injector offers a promising approach for minimally invasive drug delivery.
Dielectric breakdown is more suitable for deep skin penetration due to its pressure scalability.
The technology is well-suited for uniform drug injection over large areas and precise intradermal dosage control.